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Oral Anti Estrogen Steroids Tamoxifen For Cancer Treatment CAS 10540-29-1
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1.Quick Detail:
Product name: Tamoxifen
CAS No: 10540-29-1
Einecs No: 234-118-0
MF: C26H29NO
MW: 371.51
Purity: 99%
Appearance: white powder.
Usage: Tamoxifen citrate, a non-steroidal antiestrogen for oral administration, is commonly by athletes as a post cycle therapy drug to reduce or prevent the formation of excess estrogens that can lead to oily skin, acne, fluid retention, and gynecomastia.
2.Description:
Nolvadex (tamoxifen citrate) is very comparable to Clomid, behaves in the same manner in all tissues, and is a mixed estrogen agonist/antagonist of the same type as Clomid. The two molecules are also very similar in structure. It is not correct that Nolvadex reduces levels of estrogen: rather, it blocks estrogen from estrogen receptors and, in those tissues where it is an antagonist, causes the receptor to do nothing.
The belief that it reduces gains seems to stem from the fact that the scientific literature reports a slight reduction in IGF-1 (individuals using anabolic steroids were not studied though) from use of Nolvadex.
Thus, Dan Duchaine reported that it reduces IGF-1 and therefore reduces gains. However, if this effect exists at all, it must be very minor, due to the excellent gains that many have made, and from the fact that no one has noticed any such thing from Clomid, which has the same activity profile.
3.Application:
For the treatment of advanced, recurrent breast cancer and ovarian cancer and other illnesses. Used as an antineoplastic raw materials. Biological Activity: Estrogen receptor antagonist/partial agonist. Selective and potent inhibitor of mammalian sterol isomerase. Neuroprotective in female rats in vivo . Also high affinity agonist at the membrane estrogen receptor GPR30.
Tamoxifen non-steroidal anti-estrogen drugs. The structure similar to estrogen, the presence of two Z and E isomers. Both of different physical and chemical properties, physiological activity is different, E type having a weak estrogenic activity, Z-type having the anti-estrogen.
If the estrogen receptor (ER) within breast cancer cells, the tumor cells into estrogen, in combination therewith, and m-RNA induce DNA synthesis of tumor cells, stimulation of tumor cell growth. While tamoxifen Z isomer into the cell, binding to ER compete to form receptor complexes, stop to play the role of estrogen, thereby inhibiting the proliferation of breast cancer cells.
